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citizenry with certain genetic marker may be at high risk for marijuana dependence , a new study suggests .
investigator determine a tie between three genetical markers and symptom ofmarijuana dependence , a condition in which people ca n’t contain using the drug even though it interferes with many aspects of their lives , such as their kinship or their task .
What ’s more , the cogitation showed some convergence between the hereditary risk of exposure constituent for marijuana dependency and thegenetic risk factors for depression , suggesting a potential cause why these two conditions often go on together , the researchers said .
The study is the first to name specific transmissible markers linked with marijuana dependency . However , much more research is needed in monastic order to support the determination and understand how these genetic factors might add to marijuana dependence , the researchers enjoin .
The investigators desire the raw findings will aid contribute to a better agreement of the biological science of marijuana dependence , say study co - author Dr. Joel Gelernter , a prof of psychiatry , genetic science and neuroscience at Yale University School of Medicine in Connecticut .
In plus , future research into the genetic science of marijuana dependence could perhaps identify raw targets for medication to address the upset , Gelernter said . Currently , there are no drugs commend to treat the status , according to the National Institute on Drug Abuse ( NIDA ) .
It ’s estimated that 9 percent of people who use marijuana will become dependent on it , according to the NIDA .
" We hope our findings help bring more consciousness to the world that cannabis utilization is often not benignant and can conduct to dependence , especially in someone at high genetic danger , " Gelernter assure Live Science . [ 11 Odd Facts About Marijuana ]
In the study , Gelernter and his colleagues analyse information from more than 14,000 Americans who took part in one of three studies wait into the genetics of substance - use disorders . Between 18 and 36 percentage of the people in these studies had marijuana dependance . The investigator look for genetical variations , known as single - nucleotide polymorphism , or single nucleotide polymorphism , that were linked with symptoms of marijuana dependance .
The study recover three genetic variants that were connect with symptoms of marijuana dependency . One of these genetic variants was located in a factor involve in regulate calcium concentration in blood . late studies have found that calcium signal in the torso is important in other nub - exercise disorderliness , like opioid dependence , Gelernter aver .
Another transmitted version was situate in a cistron called CSMD1 , which is involve in the emergence of the cardinal nervous organization . Intriguingly , genetic variants within CSMD1 have also been link withschizophrenia risk(although not the same variation that were found in the new study ) , Gelernter said . antecedently studies have also found that marihuana use betimes in life is linked with an increased risk of infection of dementia praecox .
It ’s important to take note that the study regain only an association between these genetic markers and symptoms of marijuana dependence , and can not prove that these genetical mark actually cause marijuana dependence .
In addition , although the finding suggest that marijuana addiction , clinical depression and schizophrenia might partake some fundamental genetical gene , it ’s also potential that people with depression or schizophrenic disorder may use marijuana because they feel the drug mitigates some of their symptoms , the research worker said .
The cogitation is issue today ( March 30 ) in the journal JAMA Psychiatry .
