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Fruit fly that eat high - fat diet get fat , according to a new cogitation . More significant , fruit fly front obesity take care much like human corpulency , with symptoms let in mellow cholesterol and bloodline sugar imbalance .
Researchers use fruit flies as model organisms for hit the books many medical and biologic question , but much obesity research has been done on mouse . Doing alike research onfruit flieswould be easier and cheaper , since their spirit distich are shorter and their care is less expensive .
Illustration of a female and male fruit fly.
But first , researchers have to be sure fruit fly are similar enough to human being for the consequence to be useful . In 2009 , researchers pinpointed neurons in the flies ' brains that smell out and wangle the insects ' fat storehouse . The findings , reported in the journal Neuron , paralleled finding about the control of fertile storage in mammalian brains .
Like last year ’s inquiry , the new study observe parallels between flies and people . The results indicate that thedisease of obesitygoes right smart back , said study researcher Sean Oldham of the Sanford - Burnham Medical Research Institute in La Jolla , Calif.
" The capacity for this disease has been around for 500 million years , " Oldham said in a statement .
flesh out up fly sheet
To fatten up the fruit flies in their study , Oldham and his colleagues fed the louse a diet consisting of 30 percentage blubber in the shape of coco oil . Due to their hard exoskeletons , yield tent-fly can only gain so much , but the high - fat diet flies did put on weight .
On top of their chubbiness , the fly testify thefamiliar sign of obesityin humans : eminent triglycerides ( a form of fat found in the bloodstream , usually measured during cholesterol tests ) , disruptions in the balance between profligate bread and the fat - regulating hormone insulin , and even centre dysfunction reminiscent of those find in diabetes .
" The fly nub become less efficient , " study co - source Rolf Bodmer , also of the Sanford - Burnham Institute , said in a financial statement .
The determination that fat - eating fly front gain weight may seem obvious , but it ’s an significant step in establishing a yield tent-fly modelling for fleshiness , the researchers wrote in the November issue of the journal Cell Metabolism . Testing fleshiness treatments on cheap , easy - to - climb model organisms like rainfly would be unimaginable if the insects did n’t respond to flesh out the same way mammals do .
Teasing out corpulency
The researcher are n’t yet certain if the rudimentary causes for the flies ' troubles are the same as those forobese humans . They did see that one line of cellular communication , a serial of signals call the insulin / TOR tract , is involved in fly obesity . Treatments that dampened the insulin / TOR nerve tract prevented the accumulation of superfluous avoirdupois in the flies and protected their hearts .
" When we cook this pathway in the hearts of tent flap , they are still obese , but their essence is ' unreasoning ' to the systemic burden , " Bodmer said .
The researcher hope the finding could be an early clue for the treatment of human corpulency . They also trust to apply flies to sort out the complex genetic influences on obesity .
